Monophasic vs Biphasic Dermal Fillers

When it comes to anti-aging treatments, hyaluronic acid (HA) dermal fillers have become a popular choice for those looking to enhance their appearance. These fillers are substances injected into the skin to add volume, smooth out wrinkles and create a more youthful look. However, not all dermal fillers are created equal. In this blog article, we will explore the differences between monophasic vs biphasic HA dermal fillers and their advantages and disadvantages. Learn more about dermal fillers here.

Monophasic vs Biphasic Dermal Fillers: What is Monophasic Dermal Fillers

Monophasic dermal fillers are composed of a single-phase hyaluronic acid, meaning they have a consistent molecular structure throughout the filler substance. The main ingredient in these fillers is hyaluronic acid (HA), which is a substance naturally found in the skin that keeps it hydrated and supple. Today, monophasic HA fillers are the most popular and widely used dermal fillers in Malaysia and globally.


The advantages of monophasic dermal fillers include their smooth consistency. Because they are a uniform substance, they are more cohesive (Not to break apart easily), hence they distribute evenly once injected. Its superior cohesivity properties also make it less likely to migrate once injected into the skin. This creates a seamless, natural-looking result. Research also shows that monophasic fillers also tend to be more long-lasting than biphasic fillers.

Test showing monophasic fillers (Belotero, Juvederm) show superior cohesivity (Not to break apart) compared to biphasic fillers (Restylane)

Due to their cohesivity, one disadvantage of monophasic fillers is that they may be harder to inject (High extrusion force) compared to biphasic fillers. Several studies also noted that monophasic fillers tend to have lower projecting capacity, hence more volume may be needed to fill deeper facial creases or wrinkles.

Monophasic vs Biphasic Dermal Fillers: What is Biphasic Dermal Fillers

Biphasic dermal fillers, also known as two-phase fillers, are composed of two distinct phases, including an organic phase and an aqueous phase. The organic phase is typically a cross-linked HA gel, while the aqueous phase is usually a non-cross-linked HA liquid. The two phases are combined to form the filler substance.

Biphasic fillers tend to have a thicker consistency and stronger projection capacity, making them more suitable for deeper wrinkles and areas where more volume is needed. In general, biphasic HA fillers tend to be easier to inject (lower extrusion force).

Salti G, Fundarò SP. Evaluation of the Rheologic and Physicochemical Properties of a Novel Hyaluronic Acid Filler Range with eXcellent Three-Dimensional Reticulation (XTR™) Technology. Polymers (Basel). 2020 Jul 24;12(8):1644. doi: 10.3390/polym12081644. PMID: 32722003; PMCID: PMC7463506.

This study demonstrates that biphasic HA fillers (Restylane, NASHA) have higher G’ (Harder more elastic filler) compared to monophasic HA fillers (XTR, XYC and CPM). Although biphasic HA fillers tend to be more elastic (Harder filler), it is still unsure that this contributes to better lifting capacity. Some studies demonstrate that G’ is not the sole factor determining the projecting capacity of a filler.

One disadvantage of biphasic dermal fillers is that they may not distribute as evenly as monophasic fillers, which can result in lumpiness and less natural-looking results.

So Which is better? Monophasic or Biphasic Fillers

Both monophasic and biphasic dermal fillers have their advantages and disadvantages. Monophasic fillers are more consistent and long-lasting, while biphasic fillers are stronger and might have a slight advantage in terms of tissue projection. The choice between the two will depend on the individual patient’s needs and desired outcome.

Overall, dermal fillers remain a popular and effective way to enhance one’s appearance and fight the signs of ageing. While using the right and good quality product is important, it is equally crucial to ensure that the treatment is delivered skillfully to achieve your desired result. Hence, it is important to consult with a qualified and experienced provider to determine the best treatment plan and which type of dermal filler will be most effective for your individual needs.